21 C.F.R. § 1310.02

Substances covered

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The following chemicals have been specifically designated by the Administrator of the Drug Enforcement Administration as the listed chemicals subject to the provisions of this part and parts 1309 and 1313 of this chapter. Each chemical has been assigned the DEA Chemical Code Number set forth opposite it.

(a) List I chemicals

(1) Alpha-phenylacetoacetonitrile and its salts, optical isomers, and salts of optical isomers (APAAN)	8512
(2) Anthranilic acid, its esters, and its salts	8530
(3) Benzyl cyanide	8735
(4) Ephedrine, its salts, optical isomers, and salts of optical isomers	8113
(5) Ergonovine and its salts	8675
(6) Ergotamine and its salts	8676
(7) N-Acetylanthranilic acid, its esters, and its salts	8522
(8) Norpseudoephedrine, its salts, optical isomers, and salts of optical isomers	8317
(9) Phenylacetic acid, its esters, and its salts	8791
(10) Phenylpropanolamine, its salts, optical isomers, and salts of optical isomers	1225
(11) Piperidine and its salts	2704
(12) Pseudoephedrine, its salts, optical isomers, and salts of optical isomers	8112
(13) 3,4-Methylenedioxyphenyl-2-propanone	8502
(14) Methylamine and its salts	8520
(15) Ethylamine and its salts	8678
(16) Propionic anhydride	8328
(17) Isosafrole	8704
(18) Safrole	8323
(19) Piperonal	8750
(20) N-Methylephedrine, its salts, optical isomers, and salts of optical isomers (N-Methylephedrine)	8115
(21) N-Methylpseudoephedrine, its salts, optical isomers, and salts of optical isomers	8119
(22) Hydriodic Acid	6695
(23) Benzaldehyde	8256
(24) Nitroethane	6724
(25) Gamma-Butyrolactone (Other names include: GBL; Dihydro-2 (3H)-furanone; 1,2-Butanolide; 1,4-Butanolide; 4-Hydroxybutanoic acid lactone; gamma-hydroxybutyric acid lactone)	2011
(26) Red phosphorus	6795
(27) White phosphorus (Other names: Yellow Phosphorus)	6796
(28) Hypophosphorous acid and its salts (Including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite and sodium hypophosphite)	6797
(29) N-phenethyl-4-piperidone (NPP)	8332
(30) Iodine	6699
(31) Ergocristine and its salts	8612
(32)N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide (benzylfentanyl) and its salts	8334
(33) N-phenylpiperidin-4-amine (4-anilinopiperidine; N-phenyl-4-piperidinamine; 4-AP), its amides, its carbamates, its halides, its salts, and any combination thereof, whenever the existence of such is possible	8335
(34) 3,4-MDP-2-P methyl glycidate (PMK glycidate) and its optical and geometric isomers	8535
(35) 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) and its salts, optical and geometric isomers, and salts of isomers	8525
(36) Alpha-phenylacetoacetamide (APAA) and its optical isomers	8515
(37) methyl alpha-phenylacetoacetate (MAPA; methyl 3-oxo-2-phenylbutanoate) and its optical isomers	8795
(38) 4-piperidone (piperidin-4-one), its acetals, its amides, its carbamates, its salts, and salts of its acetals, its amides, and its carbamates, and any combination thereof, whenever the existence of such is possible.	8330
(39) 1-boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) and its salts	8336
(40) 1-boc-4-piperidone (tert-butyl 4-oxopiperidine-1-carboxylate) and its salts	8331
(41) Propionyl chloride	8337
(42) P2P methyl glycidic acid (2-methyl-3-phenyloxirane-2-carboxylic acid; BMK glycidic acid) and its esters, its optical and geometric isomers, its salts, salts of its optical and geometric isomers and its esters, and any combination thereof, whenever the existence of such is possible, including the following:	8526
(i) Methyl ester of P2P methyl glycidic acid (methyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P methyl glycidicate; BMK methyl glycidicate)
(ii) Ethyl ester of P2P methyl glycidic acid (ethyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P ethyl glycidicate; BMK ethyl glycidicate)
(iii) Propyl ester of P2P methyl glycidic acid (propyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P propyl glycidicate; BMK propyl glycidicate)
(iv) Isopropyl ester of P2P methyl glycidic acid (isopropyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P isopropyl glycidicate; BMK isopropyl glycidicate)
(v) Butyl ester of P2P methyl glycidic acid (butyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P butyl glycidicate; BMK butyl glycidicate)
(vi) Isobutyl ester of P2P methyl glycidic acid (isobutyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P isobutyl glycidicate; BMK isobutyl glycidicate)
(vii) sec-Butyl ester of P2P methyl glycidic acid (sec-butyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P sec-butyl glycidicate; BMK sec-butyl glycidicate
(viii) tert-Butyl ester of P2P methyl glycidic acid (tert-butyl 2-methyl-3-phenyloxirane-2-carboxylate; P2P tert-butyl glycidicate; BMK tert-butyl glycidicate

(b) List II chemicals:

(1) Acetic anhydride	8519
(2) Acetone	6532
(3) Benzyl chloride	8570
(4) Ethyl ether	6584
(5) Potassium permanganate	6579
(6) 2-Butanone (or Methyl Ethyl Ketone or MEK)	6714
(7) Toluene	6594
(8) Hydrochloric acid (including anhydrous hydrogen chloride)	6545
(9) Sulfuric acid	6552
(10) Methyl Isobutyl Ketone (MIBK)	6715
(11) Sodium Permanganate	6588

(c) The Administrator may add or delete a substance as a listed chemical by publishing a final rule in the Federal Register following a proposal which shall be published at least 30 days prior to the final rule.

(d) Any person may petition the Administrator to have any substance added or deleted from paragraphs (a) or (b) of this section.

(e) Any petition under this section shall contain the following information:

(1) The name and address of the petitioner;

(2) The name of the chemical to which the petition pertains;

(3) The name and address of the manufacturer(s) of the chemical (if known);

(4) A complete statement of the facts which the petitioner believes justifies the addition or deletion of the substance from paragraphs (a) or (b) of this section;

(5) The date of the petition.

(f) The Administrator may require the petitioner to submit such documents or written statements of fact relevant to the petition as he deems necessary in making a determination.

(g) Within a reasonable period of time after the receipt of the petition, the Administrator shall notify the petitioner of his decision and the reason therefor. The Administrator need not accept a petition if any of the requirements prescribed in paragraph (e) of this section or requested pursuant to paragraph (f) of this section are lacking or are not clearly set forth as to be readily understood. If the petitioner desires, he may amend and resubmit the petition to meet the requirements of paragraphs (e) and (f) of this section.

(h) If a petition is granted or the Administrator, upon his own motion, proposes to add or delete substances as listed chemicals as set forth in paragraph (c) of this section, he shall issue and publish in the Federal Register a proposal to add or delete a substance as a listed chemical. The Administrator shall permit any interested person to file written comments regarding the proposal within 30 days of the date of publication of his order in the Federal Register. The Administrator will consider any comments filed by interested persons and publish a final rule in accordance with his decision in the matter.

[54 FR 31665, Aug. 1, 1989, as amended at 56 FR 48733, Sept. 26, 1991; 57 FR 43615, Sept. 22, 1992; 60 FR 19510, Apr. 19, 1995; 60 FR 32460, June 22, 1995; 62 FR 5917, Feb. 10, 1997; 65 FR 21647, Apr. 24, 2000; 65 FR 47316, Aug. 2, 2000; 66 FR 52675, Oct. 17, 2001; 71 FR 60826, Oct. 17, 2006; 72 FR 20046, Apr. 23, 2007; 72 FR 35391, July 2, 2007; 72 FR 40238, July 24, 2007; 76 FR 17781, Mar. 31, 2011; 82 FR 32460, July 14, 2017; 85 FR 20828, Apr. 15, 2020; 86 FR 24707, May 10, 2021; 86 FR 64366, Nov. 18, 2021; 87 FR 67552, Nov. 9, 2022; 88 FR 21909, Apr. 12, 2023; 88 FR 74358, Oct. 31, 2023; 90 FR 47566, Oct. 2, 2025; 91 FR 16836, Apr. 3, 2026]

Notes of Decisions

Cited in 10 cases, 1991–2016 · leading case: United States v. Robert A. Tate, 822 F.3d 370 (7th Cir. 2016).

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United States v. Robert A. Tate, 822 F.3d 370 (7th Cir. 2016). “List I and II chemicals appear at 21 C.F.R. § 1310.02 of the regulations and include a few additional chemicals that do not appear in the statute, but anhydrous ammonia is not among them.”

United States v. Prather, 205 F.3d 1265 (11th Cir. 2000). “§§ 802 (33) and 802(34), and 21 C.F.R. § 1310.02 (a)(ll), because it can be used as an ingredient to manufacture methamphetamine, a controlled substance.”

Zhenli Gon v. Gerald Holt, 774 F.3d 207 (4th Cir. 2014). · cites it 2× “§ 802 (34)(K) and 21 C.F.R. § 1310.02 (a)(11); that he built a plant capable of manufacturing pseudoephedrine and other psychotropic substances, despite lacking the Mexican permit necessary to do so; that workers in this plant produced over 600 kilograms a day of a “white…”

United States v. Beckstead, 500 F.3d 1154 (10th Cir. 2007). “§ 802 (34)(K); 21 C.F.R. § 1310.02 (a)(25), while iodine is a list II chemical, 21 U.”

United States v. John Dale Ramsdale, Charles Christoferson, 61 F.3d 825 (11th Cir. 1995). “); 21 C.F.R. § 1310.02 . 2 . "Original Scents, Incorporated.”

United States v. Robert Jesse Smallwood, 920 F.2d 1231 (5th Cir. 1991). “31665 (1989) (codified at 21 C.F.R. § 1310.02 (1990)).”

In Re the Extradition of Zhenly Ye Gon, 768 F. Supp. 2d 69 (D.D.C. 2011). “Although Ye Gon contends that N-Acetylpseudoephedrine and the form of ephedrine acetate imported by him are not controlled substances and are not listed chemicals under United States law, and that therefore, their importation and transportation would not be unlawful in the…”

United States v. Landsaw, 94 F. App'x 714 (10th Cir. 2004). “§ 841 (a)(1) and § 841(c); 21 C.F.R. § 1310.02 (a)(3). The district court found that while in the house, Landsaw had purchased pseudoephedrine from the Cl, who was wearing a transmitting wire.”

In Re: In the Matter of the Extradition of Zhenly Ye Gon (D.D.C. 2011). “§ 802 (34)(c) and (K); 21 C.F.R. §§ 1310.02 (a)(3) and (a)(11). 23 purpose of repeatedly violating Mexican laws concerning narcotics and controlled psychotropic substances and/or money laundering.”

United States v. Prather, 205 F.3d 1265 (11th Cir. 2000). “§§ 802 (33) and 802(34), and 21 C.F.R. § 1310.02 (a)(11), because it can be used as an ingredient to manufacture methamphetamine, a controlled substance.”

Annotations are extracted automatically from the opinions in the Syfert caselaw corpus and ranked by authority, recency, and treatment. Dots show Syfertize treatment of the citing case itself.